Page 1: 0000090129
Log in for more options!
August 26,
198!
TOBACCO
A WEEKLY LITERATURE S ELECTION
FOR
Brown & Wi|tiamson Tobacco Corporation
Louisville, Kentucky
BY
PETERS TECHNOLOGY TRANSFER
SWARTHMORE, PENNA.
Page 3: 0000090129
Log in for more options!
O0004H
Lymphoid and Plasma Cell Malignancies: Asbestos-related
Disorders of Long Latency
ELLtOVf KAGAN, MD. AND ROBERT J JACOBSEN, M.D,, F+A,C,P,
We/lave itlenftfit~l [3 asbeslo~ workers ~th Iymphop]asr~l.a-
• cyg˘ neop]~tsm$: $1x with chr~mlc lympl~ecyt~e leuI~emi~t, four
"~hh leg myeloma, two with lea myeioma* and one with his-
|iecytie lymphoma. The subjects' occupaflon~ were +~rled~ but
_ ell had experienced prOlraeted *l~be~l(l~ ˘~;po~ure {} or I~) [}lhez
pos~bh? etinlugie ~faclo~s.
We prm.iously doeumenled three inMane~ tlf a~.ftes-
los-as.,-aldaled ile{}cloma, six of chronic 13 mphoeylic leuke
mia. and one.offt[srioeytie Iympho ha.
Materials and ~Ieth~,ds
Three eases were reporled previ~ ffsly {} other physicians.
were referred to us for hematologic[ }praisa[ because of
our interest in zsbestos-associated}'9~ematologic disor-
ders. A definite history of oeuupat ~al asbestos expo-.
sure wa~ elicited in all instances. E' palienl had been
~'alu.~.~d prc'douS!y for t fie presen~ ~or asbes,os-relaled
i~ulmonary disease, as evidenced by parencft ymal fibro-
gig, pleural plaques, bronchoge~ic Carcinoma, or malig-
nant mes~thelioma. The diagnosis of pulmona~ disease
was established by chest radiography (patients 1-3. 5-
9. 11+ and 13). computerize tomo~braphy (patienls 2.
5, and 13). thomcommy (patients 2, 4. 12. and 13) and/
or necropsy examination patients 3 and 4).
Ih.nra/oh~gic Eva/Ualhm
The diagnosis of chronic lyraphocyllc leukemia ~as
based on 1he pre~enee of a persistent ~ymphoc~aosis in
the peripheral blood and bone malTow. Myeloma was
diagnosed on Ihe basis of an abnormal marrow plas-
maeytosis (exceeding 15% of nucleated cells) in assoei-
l,-a,
I.a,,